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NEUROENDOCRINOLOGY
LETTERS
including
Psychoneuroimmunology, Neuropsychopharmacology,
Reproductive Medicine, Chronobiology
and Human Ethology, ISSN 0172–780X
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NEL
Vol.24 Nos.3/4, Jun-Aug 2003
ORIGINAL ARTICLE
Running
Title:
Gastric emptying in subclinical hyperthyroidism
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2003;
24:255–258
pii: NEL243403A17
PMID: 14523366
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Gastric
emptying in subclinical hyperthyroidism
Gurcan
Kisakol 1, Ertugrul Kayacetin 2, Oktay Sari
3
& Ahmet Kaya 1
1.
Selcuk University Meram Medical Faculty, Internal Medicine,
Division of Endocrinology and Metabolism;
2.
Selcuk University Meram Medical Faculty, Internal Medicine,
Division of Gastroenterology;
3.
Selcuk University Meram Medical Faculty, Department of Nuclear
Medicine;
KONYA/TURKEY
Submitted:
February 24, 2003
Accepted: March 12, 2003
Key
words:
subclinical hyperthyroidism, gastric emptying, 99mTc sulfur
colloid
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Abstract
INTRODUCTION
AND AIM: About 15% of hyperthyroid patients suffer from
gastrointestinal symptoms such as diarrhea, constipation,
nausea and early satiety the problem. Published reports on
the topic of gastric emptying in hyperthyroidism are rare
and discrepant in their results.
PATIENTS
AND METHODS: Thirteen patients (8 women, 5 male; aged
41.92±1.491 SE yr) with a recently established diagnosis
of subclinical hyperthyroidism due to Graves-Basedow disease
and as control group 10 age-matched healthy subject (7 women,
3 male; 39.6±2.918 SE yrs) participated in this study.
Scintigraphic method (food labeled with 99mTc sulfur colloid)
was used for measurement of gastric emptying.
RESULTS:
Gastric emptying time was similar in both subclinical hyperthyroid
and control groups (p=0.413).
DISCUSSION:
There are few studies on the subject of gastric emptying in
hyperthyroidism with either delayed emptying or with emptying
time similar to controls. In the only one study in subclinical
hyperthyroidism, gastric emptying was found to be delayed.
We also found that gastric emptying was delayed in subclinical
hyperthyroidism. On the basis of this and other studies, we
may suggest that in subclinical hyperthyroidism, gastric emptying
of solids were similar to that in age-matched healthy control
subjects and gastrointestinal dysfunction is dependent on
severity of the hyperthyroid state and might be a result of
impaired neuro-hormonal regulation. Yet the data must be supported
on larger groups.
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__________________________________________________________
Copyright © Neuroendocrinology Letters 2003
Society of Integrated Sciences
All rights reserved. No part may be reproduced, stored in a
retrieval system, or transmitted in any form or by any means,
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without prior written permission from the Editor-in-Chief.
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