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NEUROENDOCRINOLOGY
LETTERS
including
Psychoneuroimmunology, Neuropsychopharmacology,
Reproductive Medicine, Chronobiology
and Human Ethology, ISSN 0172–780X
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NEL
Vol.24 Nos.3/4, Jun-Aug 2003
ORIGINAL ARTICLE
Peptides of pineal gland and thymus prolong human life
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2003;
24:233–240
pii: NEL243403A14
PMID: 14523363
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Peptides
of pineal gland and thymus prolong human life
Vladimir
Kh. Khavinson & Vyacheslav G. Morozov
Submitted:
January 27, 2003
Accepted: February 22, 2003
Key
words:
thymus, epiphysis, peptides, geroprotectors, Thymalin,
Epithalamin, aging, life span
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Abstract
OBJECTIVES
AND DESIGN. Researchers of the St. Petersburg Institute
of Bioregulation and Gerontology of the North-Western Branch
of the Russian Academy of Medical Sciences and the Institute
of Gerontology of the Ukrainian Academy of Medical Sciences
(Kiev) clinically assessed the geroprotective effects of thymic
(Thymalin) and pineal (Epithalamin) peptide bioregulators
in 266 elderly and older persons during 6–8 years. The
bioregulators were applied for the first 2–3 years of
observation.
RESULTS.
The obtained results convincingly showed the ability of
the bioregulators to normalize the basic functions of
the human organism, i.e. to improve the indices of cardiovascular,
endocrine, immune and nervous systems, homeostasis and metabolism.
Homeostasis restoration was accompanied by a 2.0–2.4-fold
decrease in acute respiratory disease incidence, reduced incidence
of the clinical manifestations of ischemic heart disease,
hypertension disease, deforming osteoarthrosis and osteoporosis
as compared to the control. Such a significant improvement
in the health state of the peptide-treated patients correlated
with decreased mortality rate during observation: 2.0–2.1-fold
in the Thymalin-treated group; 1.6–1.8-fold in the Epithalamin-treated
group; 2.5-fold in the patients treated with Thymalin plus
Epithalamin as compared to the control. A separate group of
patients was treated with Thymalin in combination with Epithalamin
annually for 6 years and their mortality rate decreased 4.1
times as compared to the control.
CONCLUSIONS.
The obtained data confirmed the high geroprotective efficacy
of Thymalin and Epithalamin and the expediency of their application
in medicine and social care for health maintenance and age-related
pathology prevention in persons over 60 to prolong their active
longevity.
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__________________________________________________________
Copyright © Neuroendocrinology Letters 2003
Society of Integrated Sciences
All rights reserved. No part may be reproduced, stored in a
retrieval system, or transmitted in any form or by any means,
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without prior written permission from the Editor-in-Chief.
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