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NEUROENDOCRINOLOGY
LETTERS
including
Psychoneuroimmunology, Neuropsychopharmacology,
Reproductive Medicine, Chronobiology
and Human Ethology, ISSN 0172–780X
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NEL
Vol.24 Nos.3/4, Jun-Aug 2003
ORIGINAL ARTICLE
Direct effects of cocaine-amphetamine-regulated transcript (CART)
on pituitary hormone release in pituitary cell culture
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2003;
24:224–226
pii: NEL243403A12
PMID: 14523361
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Direct
effects of cocaine-amphetamine-regulated transcript (CART)
on pituitary hormone release in pituitary cell culture
Boguslawa
Baranowska, Ewa Woliñska-Witort, Magdalena
Chmielowska, Lidia Martyñska & Agnieszka
Baranowska-Bik
Neuroendocrinology
Dept. Medical Centre of Postgraduate Education Warsaw, POLAND.
Submitted:
April 7, 2003
Accepted: May 1, 2003
Key
words:
CART, pituitary hormones, cell culture
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Abstract
OBJECTIVE:
Cocaine- and amphetamine-regulated transcript (CART) is widely
expressed in the rat brain, especially in the hypothalamic
nuclei and in the anterior pituitary. The aim of this study
was to evaluate the effects of CART on pituitary hormone release
in pituitary cell culture.
MATERIAL
AND METHODS: The pituitary hormone release from pituitary
cell culture after CART administration was investigated. Concentrations
of LH, FSH, PRL, TSH and GH were measured with RIA methods.
RESULTS:
CART in all doses (1nMol, 10nMol, 100nMol) stimulated prolactin
(PRL) release and inhibited TSH release. CART administration
caused a dose dependent decrease in LH release. CART did not
change GH release from cultured pituitary cells.
CONCLUSION:
CART may affect directly pituitary hormones release in the
cell culture.
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__________________________________________________________
Copyright © Neuroendocrinology Letters 2003
Society of Integrated Sciences
All rights reserved. No part may be reproduced, stored in a
retrieval system, or transmitted in any form or by any means,
electronic, mechanical, photocopying, recording, or ortherwise,
without prior written permission from the Editor-in-Chief.
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