NEUROENDOCRINOLOGY LETTERS
including Psychoneuroimmunology, Neuropsychopharmacology,
Reproductive Medicine, Chronobiology and Human Ethology
ISSN 0172–780X

NEL Vol.23 No.2, April 2002

Season's Appreciations

2002; 23:170-187
pii: NEL220601X01
PMID:

pdf in process

Season’s Appreciations 2001

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Franz Halberg,1
Germaine Cornélissen,1
Christopher Bingham,1
Dewayne Hillman,1
George Katinas,1
Mary Sampson,1
Miguel Revilla, 2
Pavel Prikryl Sr,3
Pavel Prikryl Jr,3
Salvador Sanchez de la Pena, 4
Clicerio Gonzalez,4
Christine Amory-Mazaudier,5
Josette Bouvet,5
Franklin Barnwell,1
Cristina Maggioni,6
Robert B Sothern,1
Zhengrong Wang,7
Othild Schwartzkopff,1
Earl E Bakken, 8

1. University of Minnesota, Minneapolis, Minnesota, USA
2. University of Valladolid, Valladolid, SPAIN
3. Brno, CZECH REPUBLIC
4. Instituto Politecnico Nacional, Mexico City, MEXICO
5. CETP, Observatoire de Saint-Maur, Saint-Maur-des-Fosses, FRANCE
6. Universita degli Studi di Milano, Milan, ITALY
7. West China University of Medical Sciences, Chengdu, Sichuan, PR CHINA
8. North Hawaii Community Hospital Inc., Kamuela, Hawaii, USA

Introduction

In the third year of the center, its bibliography (citations from it are prefixed with I) shows the continuing activities of the BIOCOS (The BIOsphere in the COSmos) project. More and more time structures, chronomes, in and around us, were mapped, less and less incompletely. The cartography could be based on longer and sometimes denser time series than earlier. The cycles explored, untouchables for classical physiology, broadened in scope. From preventing diseases of individuals, we set out on a dangerous journey, leading perhaps to manageable, since physically and mathematically analyzable, physiologic mechanisms of ills of society. Hence, we mapped further internal-external interactions in aligned demographical, physiological and physical time series, including variables on fighting crime and war, Figure 1. By exclusive reliance on data, we show that by the mapping of variability inside the physiological range, the concepts of chronobiology and chronomics are more important than the putative constancy of the internal environment championed by Claude Bernard at the end of his life [1] and of homeostatic hunting and righting introduced by Walter Bradford Cannon [2]. We resolve what Bernard recognized earlier as his major discovery: the “extreme variability of the internal environment” [3], to render it useful in everyday life. In this context, the greatest news is the continuance of Healthwatch, the 7-day/24-hour blood pressure and heart rate monitoring of an entire town in Japan, under the guidance of two honorary members of our center, clinician Kuniaki Otsuka and epidemiologist Shoki Yano [photo], discussed below.
We thank the 108 co-authors worldwide who contributed this year to 69 published titles as of December 31, 2001. Franz appreciates his election to the Leibniz Society (the former Prussian academy of science), which he addressed in December 2000 and where he introduced chronomics in January 2002. We accepted an invitation extended to all of us by the geophysicist and historian Wilfried Schröder to address the Joint Scientific Assembly of the International Association of Geomagnetism and Aeronomy/International Association of Seismology and Physics of the Earth’s Interior (IAGA/IASPEI), in Hanoi from August 19-25, 2001, with new data and historical chrono-meta-analyses (I: 11-15) and met interested investigators, some now collaborating with us.

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Support
Support: U.S. Public Health Service (GM-13981); Dr. h.c. Dr. h.c. Earl Bakken Fund; University of Minnesota Supercomputing Institute.

Acknowledgments
The authors are greatly indebted to Peter G. Fedor-Freybergh, Editor-in-Chief, and to Lili Maas, Art Director, for publishing during the last few years this yearly update, originally sent to them only as information. To save space in a fine journal, the reader is referred to figures already published in earlier issues primarily of this journal and to the bibliographies available on our website.

References
1 Bernard C. Leçons sur les phénomènes de la vie communs aux animaux et aux végétaux. J.B. Bailliere, Paris, 1885.

2 Cannon WB. The Wisdom of the Body. W.W. Norton, New York, 1932, 312 pp.

3 Bernard C. De la diversité des animaux soumis à l’expérimentation. De la variabilité des conditions organiques dans lesquelles ils s’offrent à l’expérimentateur. J de l’Anatomie et de la Physiologie normales et pathologiques de l’homme et des animaux 1865; 2:497-506.

4 Cornélissen G, Kanabrocki E, Halberg J, Halberg F. Toward the chronobiology and chronomics of the intestine. In: Pierzynowski SG, Zabielski R, editors. Biology of the Intestine in Growing Animals. Elsevier NV, in press.

5 Hildebrandt G, Bandt-Reges I. Chronobiologie in der Naturheilkunde: Grundlagen der Circaseptanperiodik. Heidelberg: Haug, 1992, 102 pp.

6 Cornélissen G, Halberg F. Introduction to Chronobiology. Medtronic Chronobiology Seminar #7, April 1994, 52 pp. (Library of Congress Catalog Card #94-060580; URL [accessed 1994] http://www.msi.umn.edu/~halberg/)

7 Berger S, Kaever MJ. Dasycladales. Stuttgart: Thieme-Verlag, 1992.

8 Halberg F, Cornélissen G, Katinas G, Hillman D, Schwartzkopff O. Season’s Appreciations 2000: Chronomics complement, among many other fields, genomics and proteomics. Neuroendocrinol Lett 2001; 22:53-73.

9 Fraser-Smith AC. A weekend increase in geomagnetic activity. J Geophys Res A (Space Physics) 1979; 84:2089-2096.

10 Halberg F, Breus TK, Cornélissen G, Bingham C, Hillman DC, Rigatuso J, Delmore P, Bakken E, International Womb-to-Tomb Chronome Initiative Group: Chronobiology in space. Keynote, 37th Ann. Mtg. Japan Soc. for Aerospace and Environmental Medicine, Nagoya, Japan, November 8-9, 1991. University of Minnesota/Medtronic Chronobiology Seminar Series, #1, December 1991, 21 pp. of text, 70 figures.

11 Vladimirskii BM, Narmanskii VYa, Temuriantz NA. Global rhythmics of the solar system in the terrestrial habitat. Biophysics 1995; 40:731-736.

12 Cornélissen G, Halberg F, Schwartzkopff O, Delmore P, Katinas G, Hunter D, Tarquini B, Tarquini R, Perfetto F, Watanabe Y, Otsuka K. Chronomes, time structures, for chronobioengineering for “a full life”. Biomedical Instrumentation & Technology 1999; 33:152-187.

13 Cornélissen G, Halberg F. Geomagnetic disturbance patterns, facilitators of internally evolving, externally still resonating biological infradians: the physical evidence. Abstract, 4th International Pushchino Symposium: Relations of Biological and Physico-Chemical Processes with Space and Helio-Geophysical Factors, September 23-28, 1996, Pushchino, Moscow Region, Russia, presented by Thomas F. Peterson Jr., Cleveland, Ohio, USA.

14 Abbot CG. Solar variation and weather, a summary of the evidence, completely illustrated and documented. Smithsonian Miscellaneous Collections 146, No. 3 (Publ. 4545), Washington DC, 1963, 67 pp. + 4 plates.

15 Randall W. The solar wind and human birth rate: a possible relationship due to magnetic disturbances. Int J Biometeorol 1990; 34:42-48.

16 Otto W, Reissig G. Zur Anthropologie der Neugeborenen. 4. Mitteilung. Länge und Gewicht der Neugeborenen in den verschiedenen Monaten. Monatsberichte der Deutschen Akademie der Wissenschaften zu Berlin 1963; 5:549-559.

17 Henneberg M, Louw GJ. Further studies on the month-of-birth effect on body size: rural schoolchildren and an animal model. Am J Physical Anthropology 1993; 91:235-244.

18 Halberg F, Cornélissen G, Otsuka K, Watanabe Y, Katinas GS, Burioka N, Delyukov A, Gorgo Y, Zhao ZY, Weydahl A, Sothern RB, Siegelova J, Fiser B, Dusek J, Syutkina EV, Perfetto F, Tarquini R, Singh RB, Rhees B, Lofstrom D, Lofstrom P, Johnson PWC, Schwartzkopff O, International BIOCOS Study Group. Cross-spectrally coherent ~10.5- and 21-year biological and physical cycles, magnetic storms and myocardial infarctions. Neuroendocrinol Lett 2000; 21:233-258.

19 Garcia Alonso L, Hillman D, Cornélissen G, Garcia Penalta X, Wang ZR, Halberg F. Nature, not solely nurture: chronome as well as season governs growth patterns of infants. In: Otsuka K, Cornélissen G, Halberg F, editors. Chronocardiology and Chronomedicine: Humans in Time and Cosmos. Tokyo: Life Science Publishing, 1993: 71-75.

20 Portela A, Cornélissen G, Halberg Franz, Halberg Francine, Halberg J, Hofman MA, Swaab DF, Ikonomov OC, Stoynev AG. Metachronanalysis of circannual and circasemiannual characteristics of human suprachiasmatic vasopressin-containing neurons. In vivo 1995; 9:347-358.

21 Randall W, Randall S. The solar wind and hallucinations—a possible relation due to magnetic disturbances. Bioelectromagnetics 1991; 12:67-70.

22 Ronco A, Cornélissen G, Halberg F, Revilla M, De Stefani E. About-half-yearly pattern in the incidence of hormone-related cancers in Uruguay. Abstract #314, 5th Int. Conf. Anticancer Research, October 17-22, 1995, Corfu, Greece. Anticancer Res 1995; 15:1753.

23 Maggioni C, Cornélissen G, Antinozzi R, Ferrario M, Grafe A, Halberg F. A half-yearly aspect of circulating melatonin in pregnancies complicated by intrauterine growth retardation. Neuroendocrinol Lett 1999; 20:55-68.

24 Tarquini B, Cornélissen G, Perfetto F, Tarquini R, Halberg F. Chronome assessment of circulating melatonin in humans. In vivo 1997; 11:473-484.

25 Martikainen H, Tapanainen J, Vakkuri O, Leppaluoto J, Huhtaniemi I. Circannual concentrations of melatonin, gonadotrophins, prolactin and gonadal steroids in males in a geographical area with a large annual variation in daylight. Acta endocrinol (Copenhagen) 1985; 109:446-450.

26 Halberg F, Cornélissen G, Watanabe Y, Otsuka K, Fiser B, Siegelova J, Mazankova V, Maggioni C, Sothern RB, Katinas GS, Syutkina EV, Burioka N, Schwartzkopff O. Near 10-year and longer periods modulate circadians: intersecting anti-aging and chronoastrobiological research. J Gerontol A Biol Sci Med Sci 2001; 56:M304-M324.

27 Gavrilov LA, Gavrilova NS. Season of birth and human longevity. J Anti-Aging Med 1999; 2(4):365-366.

28 Kumagai Y, Cornélissen G, Lykken DT, Bouchard TJ Jr, Tuna N, Delmore P, Zaslavskaya R, Teibloom M, Eckert E, Halberg F. In vitro and in vivo evidence for built-in features of the human heart rate chronome. In: Cornélissen G, Halberg E, Bakken E, Delmore P, Halberg F (eds.): Toward phase zero preclinical and clinical trials: chronobiologic designs and illustrative applications. University of Minnesota Medtronic Chronobiology Seminar Series, #6, second extended edition, February 1993, Part I, pp. 47-83.

29 Schove DJ (ed.). Sunspot Cycles. Benchmark Papers in Geology/68. Stroudsburg, PA: Hutchinson Ross, 1983, 397 pp.

30 Legrand JP, Le Goff M, Mazaudier C, Schröder W. Solar and auroral activities during the seventeenth century. Acta Geod Geoph Mont Hung 1992; 27(2-4): 251-282.

31 Cornélissen G, Halberg F, Wendt HW, Bingham C, Sothern RB, Haus E, Kleitman E, Kleitman N, Revilla MA, Revilla M Jr, Breus TK, Pimenov K, Grigoriev AE, Mitish MD, Yatsyk GV, Syutkina EV. Resonance of about-weekly human heart rate rhythm with solar activity change. Biologia (Bratislava) 1996; 51:749-756.

32 Katinas GS, Halberg F, Cornélissen G, Hawkins D, Bueva MV, Korzhevsky DE, Sapozhnikova LR, Rhodus N, Schaffer E. About 8- and ~84-hour rhythms in endotheliocytes as in endothelin1 and effect of trauma. Peptides 2001; 22:647-659.

33 Simpson HW, Cornélissen G, Katinas GS, Halberg F. Meta-analysis of sequential luteal-cycle-associated changes in human breast tissue. Breast Cancer Research and Treatment 2000; 63: 171-173.

34 Sothern RB, Cornélissen G, Bingham C, Watanabe Y, Grafe A, Halberg F. Solar cycle stage: an important influence on physiology that must not be ignored. In: Proc. 3rd International Symposium of Chronobiology and Chronomedicine, Kunming, China, October 7-12, 1998. Chinese Society for Chronobiology and Chronomedicine, Chengdu, China, 1998, p. 144.

35 Lamont J. Über die zehnjährige Period, welche sich in der Grösse der täglichen Bewegung der Magnetnadel darstellt. Annalen der Physik 1851; 84(Series 2): 572-582.

36 Halberg F. Chronobiology. Ann Rev Physiol 1969; 31:675-725.

37 Gauss CF. Theorematis fundamentalis in doctrine de residuis quadraticis demonstrationes et ampliationes novae. Commentationes societatis regiae scientiarum gottingensis recentiores 1820; 4:cl. math. 3-20.

38 Schwartzkopff O, Cornélissen G, Bingham C, Homolka P, Katinas G, Sonkowsky RP, Halberg F, International BIOCOS Project Team. Long-term, when-needed lifelong monitoring concerns governments, ethics committees and everybody. Laudatio, Jarmila Siegelova’s 60th Birthday, Brno, Czech Republic, January 2002. In: Halberg F, Kenner T, Fiser B (eds). Proceedings, Symposium: The importance of chronobiology in diagnosing and therapy of internal diseases. Dedicated to the 60th anniversary of Professor Jarmila Siegelova. Faculty of Medicine, Masaryk University, Brno, Czech Republic, Jan 10-13, 2002, Brno, Masaryk University, 2002, pp 97-121.

39 Schwabe H. Über die Flecken der Sonne. Astronomische Nachrichten 1838; 15:244-248 (no. 350).

40 Schwabe H. Sonnen-Beobachtungen im Jahre 1843. Astronomische Nachrichten 1844; 21: 254-256 (no. 495).

41 Sabine E. On periodical laws discoverable in the mean effects of the larger magnetic disturbances, No. II. Philosophical Transactions, Royal Society of London, 1852; 103-124.

42 Wolf JR. Sonnenflecken-Beobachtungen in der ersten Hälfte des Jahres 1852; Entdeckung des Zusammenhanges zwischen den Declinations-variationen der Magnetnadel und des Sonnenflecken. Mittheilungen der Naturforschenden Gesellschaft in Bern 1852; 179-184.

43 Ohtsuka-Isoya M, Hayashi H, Shinoda H. Effect of suprachiasmatic nucleus lesion on circadian dentin increment in rats. Am J Physiol Regulatory Integrative Comp Physiol 2001; 280:R1364-R1370.

44 Kaiser H, Cornélissen G, Halberg F. Paleochronobiology: circadian rhythms, gauges of adaptive Darwinian evolution; about 7-day (circaseptan) rhythms, gauges of integrative internal evolution. Progress in Clinical and Biological Research 1990; 341B:755-762.

45 Prikryl P, Siegelova J, Cornélissen G, Dusek J, Dankova E, Fiser B, Vacha J, Ferrazzani S, Tocci A, Caruso A, Rao G, Fink H, Halberg F, International Womb-to-Tomb Chronome Initiative Group: Chronotherapeutic pilot on 6 persons may guide tests on thousands: Toward a circadian optimization of prophylactic treatment with daily low-dose aspirin. University of Minnesota/Medtronic Chronobiology Seminar Series, #3, December 1991, 4 pp. text, 4 figures.

46 Cornélissen G, Halberg F, Prikryl P, Dankova E, Siegelova J, Dusek J, International Womb-to-Tomb Chronome Study Group: Prophylactic aspirin treatment: the merits of timing. JAMA 1991; 266:3128-3129.

47 Tiller WA, Dibble WE, Kohane MJ. Conscious Acts of Creation: The Emergence of a New Physics. Walnut Creek, CA: Pavior, 2001, 418 pp.

48 Jahn RG. Out of this aboriginal sensible muchness: consciousness, information, and human health. J Am Soc Psychical Res 1995; 89:301-312.

49 Chizhevsky AL. The Earth in the Universe. V.V. Fedynsky ed. NASA TT F-345 TT 66-51025, 1968, 280 pp.

50 Sigel F. Vinovato solntse [The Sun is Guilty]. (Dreier W, Lerche D, German translation; Göring H, scientific editor, German edition.) Moscow: Verlag MIR/Leipzig: VEB Fachbuchverlag, 1975.

51 Ertel S. Influenza pandemics and sunspots—easing the controversy. Naturwissenschaften 1994; 82:308-310.

52 Cornélissen G, Bingham C, Siegelová J, Fiser B, Dusek J, Prikryl P, Sonkowsky RP, Halberg F. Cardiovascular disease risk monitoring in the light of chronobioethics. Chronobiologia 1994; 21:321-325.

53 Halberg F, Bingham C, Siegelová J, Fiser B, Dusek J, Prikryl P, Sonkowsky RP, Cornélissen G. “Cancer marker chronomes” assessed in the light of chronobioethics. Chronobiologia 1994; 21:327-330.

54 Goldstein LB, Adams R, Becker K, Furberg CD, Gorelick PB, Hademenos G, Hill M, Howard G, Howard VJ, Jacobs B, Levine SR, Mosca L, Sacco RL, Sherman DG, Wolf PA, del Zoppo GJ. Primary prevention of ischemic stroke: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Circulation 2001; 103:163-182.

55 Grundy SM, Pasternak R, Greenland P, Smith S Jr, Fuster V. Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations. A statement for healthcare professionals from the American Heart Association and the American College of Cardiology. Circulation 1999; 100:1481-1492.

Appendix
Publications by staff members of the University of Minnesota Halberg Chronobiology Center: 2001

1 Halberg F, Cornélissen G, Katinas G, Hillman D, Schwartzkopff O. Season’s Appreciations 2000: Chronomics complement, among many other fields, genomics and proteomics. Neuroendocrinol Lett 2001; 22:53-73.

2 Halberg F, Cornélissen G. Chronobiology: rhythms, clocks, chaos, aging, and other trends. In: Maddox GL, ed-in-chief. The Encyclopedia of Aging, 3rd ed. Springer, New York, 2001: 196-201.

3 Cornélissen G, Schwartzkopff O, Halberg F, Otsuka K, Watanabe Y. 7-day ambulatory monitoring for adults with hypertension and diabetes [letter]. Am J Kidney Diseases 2001; 37:878.

4 Katinas GS, Halberg F, Cornélissen G, Hawkins D, Bueva MV, Korzhevsky DE, Sapozhnikova LR, Rhodus N, Schaffer E. About 8- and ~84-hour rhythms in endotheliocytes as in endothelin1 and effect of trauma. Peptides 2001; 22:647-659.

5 Halberg F, Cornélissen G, Watanabe Y, Otsuka K, Fiser B, Siegelova J, Mazankova V, Maggioni C, Sothern RB, Katinas GS, Syutkina EV, Burioka N, Schwartzkopff O. Near 10-year and longer periods modulate circadians: intersecting anti-aging and chronoastrobiological research. J Gerontol A Biol Sci Med Sci 2001; 56:M304-M324.

6 Halberg F, Cornélissen G, Syutkina EV, Watanabe Y, Otsuka K, Maggioni C, Mello G, Perfetto F, Tarquini R, Haen E, Schwartzkopff O. A chronopediatric pioneer who practices prehabilitation: a tribute to Theodor Hellbrügge on his 80th birthday. Pädiatrie und Grenzgebiete 2001; 40:17-41.

7 Schaffer E, Cornélissen G, Rhodus N, Halhuber M, Watanabe Y, Halberg F. Outcomes of chronobiologically normotensive dental patients: a 7-year follow-up. JADA 2001; 132:891-899.

8 Aguilar-Roblero R, Arechiga H, Ashkenazi I, Burioka N, Cipolla Neto J, Cornélissen G, Markus R, Marques N, Menezes AAL, Monk TH, Ralph M, Valdez-Ramirez P, Menna-Barreto L. The brain decade in debate: IV. Chronobiology. Braz J Med Biol Res 2001; 34:831-841.

9 Burioka N, Cornélissen G, Halberg F, Kaplan DT. Relationship between correlation dimension and indices of linear analysis in both respiratory movement and electroencephalogram. Clin Neurophysiol 2001; 112:1147-1153.

10 Delyukov A, Gorgo Yu, Cornélissen G, Otsuka K, Halberg F. Natural environmental associations in a 50-day human electrocardiogram. Int J Biometeorol 2001; 45:90-99.

11 Holley D, Cornélissen G, Winget C, Engebretson M, Halberg F. The biological and anthropogenic week (circaseptans, CS) and half-week (circasemiseptans, CSS) and geomagnetic disturbance. Abstract 2559, IAGA-IASPEI Joint Scientific Assembly, Hanoi, Vietnam, 19-31 August 2001. IAGA-IASPEI LOC, Hanoi, 2001, p. 276.

12 Revilla M, Cornélissen G, Halberg F. Technology in the service of history. Abstract 2558, IAGA-IASPEI Joint Scientific Assembly, Hanoi, Vietnam, 19-31 August 2001. IAGA-IASPEI LOC, Hanoi, 2001, p. 281.

13 Cornélissen G, Halberg F, Weydahl A, Otsuka K, Watanabe Y, Syutkina EV, Siegelova J, Baevsky R, Breus T, Holley D, International BIOCOS Group. Geophysical associations of human heart rate variability. Abstract 2557, IAGA-IASPEI Joint Scientific Assembly, Hanoi, Vietnam, 19-31 August 2001. IAGA-IASPEI Local Organizing Committee, Hanoi, 2001, pp. 281-282.

14 Winget C, Cornélissen G, Holley D, Halberg F. Recent history of remote natural environmental factors and human myocardial infarction. Abstract 2560, IAGA-IASPEI Joint Scientific Assembly, Hanoi, Vietnam, 19-31 August 2001. IAGA-IASPEI Local Organizing Committee, Hanoi, 2001, p. 282.

15 Schwartzkopff O, Halberg F, Cornélissen G, Otsuka K, Engebretson M. From Arago’s 24-h magnetic variations to a Kp spectrum with cross-spectral coherence away from peaks of biologic near-matches. Abstract 2561, IAGA-IASPEI Joint Scientific Assembly, Hanoi, Vietnam, 19-31 August 2001. IAGA-IASPEI Local Organizing Committee, Hanoi, 2001, p. 282.

16 Aslanian NL, Halberg F, Okoev GG, Cornélissen G, Manukian LK, Iskandarian AE. [Monitoring of arterial blood pressure and heart rate in chronobiological investigations during normal and pathological pregnancy.] Reports, 6th Congress, L.A. Orbeli Armenian Physiological Society, Associate member of IUPS (since 1997), 4-7 October 2001, pp. 71-73. [In Russian.]

17 Delyukov A, Gorgo Yu, Cornélissen G, Otsuka K, Halberg F. Infradian biological rhythms in non-stationary physical environment. Abstract, International Crimean Seminar, Cosmos and Biosphere: Physical Fields in Biology, Medicine and Ecology, Partenit, Crimea, Ukraine, October 1-6, 2001, p. 183.

18 Halberg F, Cornélissen G, Otsuka K, Katinas G, Schwartzkopff O. Essays on chronomics spawned by transdisciplinary chronobiology: Witness in time: Earl Elmer Bakken. Neuroendocrinol Lett 2001; 22:359-384.

19 Halberg F. Vazeni pratele / Sehr geehrte Freunde / Dear Friends. MEFA 9th International Fair of Medical Technology and Pharmacy, Brno, November 6-11, 2001, pp. 10-15. (In Czech, German & English.)

20 Halberg F, Cornélissen G, Otsuka K, Maggioni C, Schwartzkopff O. Chronomics, the broad scope of monitoring chronomes, time structures. Abstract 8, MEFA 9th International Fair of Medical Technology and Pharmacy, Brno, November 6-11, 2001.

21 Cornélissen G, Halberg F, Otsuka K, Shinagawa M, Kubo Y, Ohkawa S, Siegelova J. Iatrogenic CHAT (excessive blood pressure variability) within the acceptable range of BP values: implications for chronotherapy? Abstract 9, MEFA 9th International Fair of Medical Technology and Pharmacy, Brno, November 6-11, 2001.

22 Schwartzkopff O, Halberg F, De Prins J, Grafe A, Cornélissen G. Intellectual climate of mapping heliogeophysical time structures — chronomes — in the 1800s, with corrections for encyclopedias. Abstract 10, MEFA 9th International Fair of Medical Technology and Pharmacy, Brno, November 6-11, 2001.

23 Otsuka K, Cornélissen G, Halberg F. Assessment of different administration schedules of sotalol by electrocardiography. Abstract 11, MEFA 9th International Fair of Medical Technology and Pharmacy, Brno, November 6-11, 2001.

24 Katinas G, Cornélissen G, Halberg F. Spectral variance shifts of the aurora borealis in the 16th-18th centuries. Abstract 12, MEFA 9th International Fair of Medical Technology and Pharmacy, Brno, November 6-11, 2001.

25 Hillman D, Cornélissen G, Halberg F, Engebretson M. Ecomedically and evolutionarily critical geophysical near-week vs. anthropogenic week. Abstract 13, MEFA 9th International Fair of Medical Technology and Pharmacy, Brno, November 6-11, 2001.

26 Sothern RB, Cornélissen G, Halberg F, Engel P. Chronomics: instrumentation for monitoring of peak expiratory flow while exercising chest and lungs. Abstract 14, MEFA 9th International Fair of Medical Technology and Pharmacy, Brno, November 6-11, 2001.

27 Nintcheu-Fata S, Cornélissen G, Katinas G, Halberg F, Fiser B, Siegelova J, Masek M, Dusek J. Software for contour maps of moving least squares spectra. Abstract 15, MEFA 9th International Fair of Medical Technology and Pharmacy, Brno, November 6-11, 2001.

28 Halberg F, Cornélissen G, Engebretson M, Siegelova J, Schwartzkopff O. Transdisciplinary biological-heliogeophysical relations at weekly, half-yearly and Hale-cycle frequencies. Scripta medica (Brno) 2001; 74:69-74.

29 Chen ChH, Cornélissen G, Siegelova J, Halberg F. Does overswinging provide an early warning of cardiovascular disease risk when non-dipping may fail ? A meta-analysis of 2039 cases. Scripta medica (Brno) 2001; 74:75-80.

30 Cornélissen G, Chen ChH, Siegelova J, Halberg F. Vascular disease risk syndromes affecting both MESOR-normotensives and MESOR-hypertensives: a meta-analysis of 2039 cases. Scripta medica (Brno) 2001; 74:81-86.

31 Ulmer W, Cornélissen G, Revilla M, Siegelova J, Dusek J, Halberg F. Circadian and circaseptan dependence of the beta-ATP peak of four different cancer cell cultures: implications for chronoradiotherapy. Scripta medica (Brno) 2001; 74:87-92.

32 Singh RB, Niaz MA, Cornélissen G, Otsuka K, Siegelova J, Fiser B, Halberg F. Circadian rhythmicity of circulating vitamin concentrations. Scripta medica (Brno) 2001; 74:93-96.

33 Uezono K, Halberg F, Cornélissen G, Watanabe Y, Siegelova J, Schwartzkopff O. Natural near-weeks of biology and geophysics differ from the man-made week: transdisciplinary meta-analytic hints. Scripta medica (Brno) 2001; 74:97-102.
34 Watanabe Y, Cornélissen G, Otsuka K. Ohkawa S, Siegelova J, Halberg F. Effect of alcohol intake and treatment with calcium antagonist on blood pressure and heart rate assessed by ambulatory monitoring. Scripta medica (Brno) 2001; 74:103-106.

35 Faraone P, Cornélissen G, Katinas GS, Halberg F, Siegelova J. Astrophysical influences on sectoring in colonies of microorganisms. Scripta medica (Brno) 2001; 74:107-114.

36 Otsuka K, Cornélissen G, Halberg F. Preface: Circadian rhythms and clinical chronobiology. Biomedicine and Pharmacotherapy 2001; 55 (suppl 1): 7-18.

37 Halberg F, Cornélissen G, Otsuka K, Katinas G, Delmore P, Schwartzkopff O. Earl Elmer Bakken: Pacing chronomics. Biomedicine and Pharmacotherapy 2001; 55 (suppl 1):19-20.

38 Cornélissen G, Engebretson M, Johnson D, Otsuka K, Burioka N, Posch J, Halberg F. The week, inherited in neonatal human twins, found also in geomagnetic pulsations in isolated Antarctica. Biomedicine and Pharmacotherapy 2001; 55(suppl 1):32-50.

39 Otsuka K, Cornélissen G, Weydahl A, Holmeslet B, Hansen TL, Shinagawa M, Kubo Y, Nishimura Y, Omori K, Yano S, Halberg F. Geomagnetic disturbance associated with decrease in heart rate variability in a subarctic area. Biomedicine and Pharmacotherapy 2001; 55(suppl 1):51-56.

40 Otsuka K, Oinuma S, Cornélissen G, Weydahl A, Ichimaru Y, Kobayashi M, Yano S, Holmeslet B, Hansen TL, Mitsutake G, Engebretson MJ, Schwartzkopff O, Halberg F. Alternating-light-darkness-influenced human electrocardiographic magnetoreception in association with geomagnetic pulsations. Biomedicine and Pharmacotherapy 2001; 55(suppl 1):63-75.

41 Weydahl A, Sothern RB, Cornélissen G, Wetterberg L. Geomagnetic activity influences the melatonin secretion at latitude 70N. Biomedicine and Pharmacotherapy 2001; 55(suppl 1):57-62.

42 Watanabe Y, Cornélissen G, Halberg F, Otsuka K, Ohkawa S-I. Association by signatures and coherences between the human circulation and helio- and geomagnetic activity. Biomedicine and Pharmacotherapy 2001; 55(suppl 1): 76-83.

43 Delyukov A, Gorgo Y, Cornélissen G, Otsuka K, Halberg F. Infradian, notably circaseptan testable feedsidewards among chronomes of the ECG and air temperature and pressure. Biomedicine and Pharmacotherapy 2001; 55 (suppl 1): 84-92.

44 Mitsutake G, Otsuka K, Cornélissen G, Herold M, Günther R, Dawes C, Burch JB, Watson D, Halberg F. Circadian and infradian rhythms in mood. Biomedicine and Pharmacotherapy 2001; 55(suppl 1):94-100.

45 Shinagawa M, Kubo Y, Otsuka K, Ohkawa S, Cornélissen G, Halberg F. Impact of circadian amplitude and chronotherapy: relevance to prevention and treatment of stroke. Biomedicine and Pharmacotherapy 2001; 55(suppl 1):125-132.

46 Halberg F, Cornélissen G, Otsuka K, Schwartzkopff O, Halberg J, Bakken EE. Chronomics. Biomedicine and Pharmacotherapy 2001; 55(suppl 1):153-190.

47 Weydahl A, Sothern RB, Cornélissen G. Nonlinear relation of heart rate variability during exercise recovery with local geomagnetic activity. Abstract 5, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (3 pp.)

48 Otsuka K, Cornélissen G, Weydahl A, Holmeslet B, Yano S, Halberg F, on behalf of the ICEHRV Working Group. Light-dependent magnetoreception mechanism in humans involving the Pc 6 band of the ULF magnetic field: heart rate variability associated with an alteration of geomagnetic activity. Abstract 6, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (2 pp.).

49 Mitsutake G, Cornélissen G, Otsuka K, Wanliss J, Halberg F. Does exposure to artificial ULF waves affect mood? Abstract 7, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (5 pp.).

50 Otsuka K, Cornélissen G, Maggioni C, Ertel S, Udaltsova N, Vaiserman A, Halberg F. Does geomagnetic activity influence human longevity? A chrono-meta-analysis. Abstract 8, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (2 pp.).

51 Vaiserman AM, Udaltsova N, Koshel NM, Belaja II, Voitenko VP, Ertel S, Cornélissen G, Halberg F. Human longevity: related to date of birth? Abstract 9, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (1 p).

52 Cornélissen G, Hillman D, Otsuka K, Halberg F. Weekend or weekday “effects” vs. natural and anthropogenic circaseptan geomagnetics. Abstract 10, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (2 pp).

53 Hillman D, Cornélissen G, Katinas G, Halberg F. Does circaseptan amplitude difference in spectrum of antipodal geomagnetic index aa gauge human magnetic pollution? Abstract 11, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (2 pp).

54 Wendt HW, Katinas G, Cornélissen G, Halberg F. About 50-year and longer cycles in the spectral elements of auroral and biospheric chronomes. Abstract 12, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (1 p).

55 Katinas G, Nintcheu-Fata S, Cornélissen G, Watanabe Y, Otsuka K, Halberg F. Spectra of relative prominence of ordering probability may reveal what amplitude spectra may miss. Abstract 13, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, November 2001, unpaginated (3 pp).

56 Schwartzkopff O, Cornélissen G, Syutkina EV, Breus TK, Garcia Alonso L, Mello G, Perfetto F, Tarquini R, Udaltsova N, Halberg F. Broadening rhythm spectrum in perinatology and pediatrics, where genetics and geo-helio-magnetics meet. Abstract 14, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (3 pp).

57 Halberg F, Cornélissen G, Otsuka K, Watanabe Y, Sothern RB, Katinas G, Mikulecky M, Maggioni C, Wilson D, Kumagai Y, Perfetto F, Tarquini R, Schwartzkopff O, Bakken E. Chronomics: transdisciplinary biospherical near-matches of circadecadal/circadidecadal/circaquindecadal environmental cycles. Abstract 15, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (6 pp).

58 Watanabe Y, Katinas G, Watanabe F, Watanabe M, Cornélissen G, Otsuka K, Halberg F. Cardiochronomics for astrobiology: infradian prominence in heart rate of a healthy boy born at term. Abstract 20, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (2 pp).

59 Halberg F, Cornélissen G, Appenzeller O, Wallace J, Acosta MA, Schwartz GT, Dean MC. Chronomics: different multiseptans in enamel of ancient and contemporaneous teeth. Abstract 22, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (4 pp).

60 Prikryl P, Neubauer J, Prikryl P Jr, Karpisek Z, Cornélissen G, Halberg F. Circadian cardiovascular rhythms and low-dose aspirin effects upon them. Abstract 25, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (1 p).

61 Maggioni C, Cornélissen G, Halberg F. Half-yearly aspect of estriol in pregnancies complicated by intrauterine growth retardation (IUGR). Abstract 26, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (1 p).

62 Sanchez de la Peña S, Gonzalez C, Cornélissen G, Halberg F. Chronomics: time structure (chronome) of blood pressure and heart rate in health and diabetes. Abstract 27, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (2 pp).

63 Mitsutake G, Otsuka K, Matsuoka O, Murakami S, Yamanaka T, Omori H, Nishimura Y, Kubo Y, Shinagawa A, Okawa S-I, Wada T, Matsubayashi K, Kobayashi M, Ichimaru Y, Yano S, Cornélissen G, Halberg F. Depression predicted by QOL factors. Abstract 30, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (2 pp). [In Japanese.]

64 Bubenik GA, Cornélissen G, Bartos L, Halberg F. Circadian, circasemidian and circaoctohoran components in the spectral element of the portal porcine circulating melatonin chronome. Abstract 33, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (1 p).

65 Aslanyan N, Kocharyan S, Cornélissen G, Gyulbudahyan R, Herold M, Halberg F. Ultradian resolution of the waveform of circulating human melatonin in health and disease. Abstract 34, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (1 p).

66 Singh RB, Srivastav V, Srivastav SSL, Akhilesh J, Cornélissen G, Halberg F. Circadian variation under conditions of caloric restriction in North India. Abstract 36, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (1 p).

67 Mahdi AA, Singh R, Singh RK Jr, Jain M, Negi N, Singh U, Misra S, Singh RK, Cornélissen G, Halberg F. Oxidative load and anti-oxidant status in gynecological malignancies. Abstract 37, 2nd International Symposium: Workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 17, 2001, unpaginated (1 p).

68 Otsuka K, Cornélissen G, Weydahl B, Holmeslet B, Halberg F, on behalf of the ICEHRV Working Group. Search for biological effects of geomagnetic disturbances in humans: heart rate variability associated with an alteration of geomagnetic activity. Abstract, 25th Meeting, International Society of Chronobiology, Kemer-Antalya, Turkey, October 9-13, 2001. Chronobiology International 2001; 18:1177-1178.

69 Weydahl A, Sothern RB, Cornélissen G. Heart rate variability during recovery from 30-minute exercise is greatest in the morning. Abstract, 25th Meeting, International Society for Chronobiology, Kemer-Antalya, Turkey, October 9-13, 2001. Chronobiology International 2001; 18:1217.