Ultrastructural
Analysis of Rat’s Hypothalamo-Neurohypophysial System in
a New Experimental Model of Clinical Death by Barbara Gajkowska & Andrzej Kapuscinski
Abstract:
The
purpose of this study was to analyze ultrastructural changes
in neurosecretory system in rats with permanent bilateral common
carotid artery occlusion that survived two months after cardiac
arrest. In this model severe ultrastructural changes in the
supraoptic and paraventricular nuclei took place. Observed damage
of neurosecretory neurons and their axons, activation of microglial
and inflammatory cells and dysfunction of blood-brain barrier
suggest reduction in the secretory process in hypothalamo-neurohypophysial
system. Our model allows to investigate the mechanism of ischemic
injury.
