Sympathetic
Regulation of Immune Response in Cadmium Exposed Mice by Shyam Bala Lall and Gargi Dan
Abstract:
Immunomodulatory
role of sympathetic nervous system (SNS) on the humoral and
cell mediated immunity (CMI) in Cadmium (Cd) exposed mice was
investigated. The effect of treatment with Cd (300 ppm), Cd+phenoxybenzamine,
Cd+propranolol and Cd+normadate on the immune response was observed
after 35 days of exposure. The results of each group were compared
with that of their respective controls. The Cd induced immunosuppressive
effect on humoral and CMI was not affected by phenoxybenzamine.
However, treatment with propranolol and normadate significantly
(p < 0.05) increased the humoral and cell mediated immunity
which was markedly suppressed when these drugs were co-administered
with Cd. The results indicate that Cd induced immunosuppression
may involve the beta adrenergic receptors.
