NEL, Estrogen-Brain Relationship During Development and Aging: Effects on Glial Cells

NeuroendocrinologyÝLetters ISSNÝ0172ñ780X CopyrightÝ©Ý1997 NeuroendocrinologyÝLetters
Contents Vol. 18-21	NEL Vol. 18 No. 4 Original Article	1998; 18:215-220 pii: NEL182397A04
Estrogen-Brain Relationship During Development and Aging: Effects on Glial Cells by R. Kapur and P S. Timiras Received: November 14, 1997 Accepted: November 24, 1997 Summary 17-b-estradiol stimulates glial cell growth beginning at 5 days in culture, the highest proliferation occuring with the highest hormone concentration. Activity of glutamine synthetase and cyclic nucleotide phosphohydrolase, markers for astrocytes and oligodendrocytes, respectively, is also increased, the highest concentration inducing the greatest activity. These changes may represent one of the mechanisms of the neuroprotective actions ofestrogens.
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NeuroendocrinologyÝLetters ISSNÝ0172ñ780X CopyrightÝ©Ý1997 NeuroendocrinologyÝLetters