NEL, Quinolinic Acid: Lipolytic Effect

NeuroendocrinologyÝLetters ISSNÝ0172ñ780X CopyrightÝ©Ý1997 NeuroendocrinologyÝLetters
Contents Vol. 18-21	NEL Vol. 18 No. 4 Original Article	1998; 18:197-201 pii: NEL182397A02
Quinolinic Acid: Lipolytic Effect by M. Beskid, J. Jachimowicz, and Z. Obminski Received: February 15, 1997 Accepted: May 6, 1997 Summary Quinolinic acid is a structural analogue of nicotinic acid. Metabolic activity of nicotinic acid is lowering the free fatty acids (FFA) level in serum by phosphodiesterase activation. Our investigations proved that quinolinic acid significantly increase FFA scrum concentration applied alone or in combination with propranolol. It seems that quinolinic acid inhibits phosphodiesterase activity in adipocytes. That leads to cyclic AMP increase, lipolytic intensity and growth of FFA serum concentration.
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NeuroendocrinologyÝLetters ISSNÝ0172ñ780X CopyrightÝ©Ý1997 NeuroendocrinologyÝLetters